GEC-KO on the run

Each GEC-KO on the run is a concise summary for healthcare providers on a genetic disorder, technology or topic.   For access to a more comprehensive summary, view or download a GEC-KO Messenger found in the left-hand menu.  Use CTRL + F function to search key words on this page.

GEC-KO Messengers and GEC-KO on the run are written by a team that includes genetic counsellors, geneticists and genetic researchers. All are reviewed by a family physician.  They are evidence-based and referenced, and feature a ‘Bottom line’ with recommendations.  They were developed as a ‘spin-off’ of the successful Gene Messengers which were part of the GenetiKit project.  Findings from this study were published and can be found in Carroll JC, Wilson BJ, Allanson J, Grimshaw J, Blaine SM, Meschino WS, Permaul JA, Graham ID. GenetiKit: a randomized controlled trial to enhance delivery of genetics services by family physicians. Fam Pract 2011; 28(6): 615-23.


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Alzheimer disease | AD | Dementia | apolipoprotein E APOE | presenilin  PSEN | amyloid  APP | LOAD | EOAD | GEC-KO on the run (2019)

Autism spectrum disorder [Genetics of] | ASD | ASDplus | Complex | chromosomal microarray | fragile X syndrome | GEC-KO on the run (2017)



BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer Syndrome | HBOC | GEC-KO on the run (2016)



Chromosomal Microarray, Prenatal | CMA | SNP | Prenatal | Technology | Ultrasound | Congenital anomaly | GEC-KO on the run (2015)

Codeine and Breastfeeding | Pharmacogenomics | SNPs | Metabolism | cytochrome P450 | CYP 2D6 | GEC-KO on the run (2018)

Colorectal Cancer | Lynch syndrome | Colorectal | Hereditary non-polyposis colorectal cancer (HNPCC) syndrome | GEC-KO on the run (2019)

Consanguinity | Preconception  counselling | Ethnicity-based screening | GEC-KO on the run (2019)



Epilepsy | Seizures | GEC-KO on the run (2019)



Diabetes Type 2 | Non-insulin dependent diabetes mellitus | NIDDM | Susceptibility | TCF7L2 | GEC-KO on the run (2014)

Direct-to-Consumer Genetic Testing | DTC | Personal Genome Testing | Technology | GEC-KO on the run (2015)



Factor V Leiden | Thrombophilia | Clotting disorder | GEC-KO on the run (2014)

Familial hypercholesterolemia | FH | cholesterol | dyslipidemia | cardiovasular disease | GEC-KO on the run (2016)



Hereditary Breast and Ovarian Cancer Syndrome | HBOC | BRCA1 | BRCA2 | GEC-KO on the run (2016)

Hereditary Hemochromatosis | HH | HFE | Iron Overload | C282Y | GEC-KO on the run (2019)

Huntington Disease | Neurodegenerative | Psychiatric | huntingtin HTT | CAG repeat | triplet repeat disorder | GEC-KO on the run (2019)

Hypertrophic Cardiomyopathy| HCM | Cardiogenetics | Sudden Cardiac Death | SCD | sarcomere | GEC-KO on the run (2014)



Long QT syndrome | LQTS | cardiogenetics | arrythmia | Sudden unexplained death | GEC-KO on the run (2016)

Lynch Syndrome | LS | Cancer | Colon | Colorectal | Hereditary non-polyposis colorectal cancer (HNPCC) syndrome | MSI | MLH | MSH | GEC-KO on the run (2019)



Non-Invasive Prenatal Testing | NIPT | Prenatal | Screening | aneuploidy | GEC-KO on the run (2015)



Microarray | Chromosomal microarray | CMA | Technology | Autism Spectrum Disorder | Developmental Delay | GEC-KO on the run (2019)

Microarray, Prenatal |  Chromosomal microarray | CMA | SNP | Prenatal | Technology | Ultrasound | Congenital anomaly | GEC-KO on the run (2015)

Multiple Sclerosis | Demyelinating | Complex inheritance | Suceptibility | GEC-KO on the run (2014)



Prenatal Chromosomal Microarray | CMA | SNP| Prenatal | Technology | Ultrasound | Congenital anomaly | GEC-KO on the run (2015)

Pharmacogenomics Codeine and Breastfeeding |  SNPs | Metabolism | cytochrome P450 | CYP 2D6 | GEC-KO on the run (2019)



Schizophrenia | Mental Illness | Complex Inheritance |  Susceptibility | Syndromic vs Isolated | GEC-KO on the run (2019)



Thrombophilia | Factor V Leiden | Clotting disorder | GEC-KO on the run (2014)

Type 2 Diabetes  | Non-insulin dependent diabetes mellitus | NIDDM | Susceptibility | TCF7L2 | GEC-KO on the run (2014)


As we are busy developing content, we are happy to hear from our users about their preferences for topics to be developed into GEC-KO Messengers.  If there is content you feel should be prioritized to better incorporate genomic medicine in your practice, please do not hesitate to contact us or tweet us @GECKOgenetics and let us know.


Currently, the website is attempting to meet the information needs of healthcare providers. As a result, when choosing content and terminology for the site, we have assumed that the reader has a certain amount of medical knowledge.

Healthcare providers must use their own clinical judgment in addition to the information presented herein. The authors assume no responsibility or liability resulting from the use of information on this website.

All healthcare providers using this site are encouraged to consult local genetics clinics, medical geneticists, or specialists for clarification of questions that arise relating to specific patient problems.

External links are selected and reviewed at the time a page is published. However, GEC-KO is not responsible for the content of external websites. The inclusion of a link to an external website from GEC-KO should not be understood to be an endorsement of that website or the site’s owners (or their products/services).

We strive to provide accurate, timely, unbiased and up-to-date information on this site, and make every attempt to ensure the integrity of the site. However, it is possible that the information contained here may contain inaccuracies or errors for which neither GEC-KO nor its funding agencies assume responsibility.