Future of clinical genomics?

Biesecker Green 2014 Exome primer

Biesecker and Green developed a primer for clinicians on how to approach clinical genome and exome sequencing (CGES).  The comprehensive summary provides a technical overview and discussion of limitations of CGES, summarizes indications for ordering and evaluation, interpretation and communication of results, and how to address incidental findings.  Additionally there is an interactive graphic overviewing the technology and providing guidance to providers in clinical context.

Biesecker LG and Green RCDiagnostic clinical genome and exome sequencing.N Engl J Med 2014; 370(25):2418-25. doi: 10.1056/NEJMra1312543.